Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids
نویسندگان
چکیده
منابع مشابه
Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids.
Gap junctional intercellular communication (GJIC) has been implicated in homeostasis, development, differentiation, wound healing or regeneration and adaptive responses of differentiated cells. The dysfunction of homologous or heterologous GJIC has been associated with the tumorigenic phenotype. Restoration of growth control and the suppression of the tumorigenic phenotype have been previously ...
متن کاملAstaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts.
Astaxanthin is a carotenoid found in plants and algae; it provides the color of marine seafood such as salmon, lobster, or shrimp. Carotenoids are antioxidants and exhibit other biological functions, including effects on gap junctional communication important for homeostasis, growth control, and development of cells. Cancer cells have an impaired gap junctional intercellular communication. The ...
متن کاملGap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells.
Gap junctional communication modulates intercellular calcium signaling in many cell types. We have investigated whether gap junctional communication modulates calcium oscillatory behavior of cells responding to an agonist. Extracellular UTP induced calcium oscillations in 70% of HeLa cells cultured in monolayer, and neighboring cells oscillated independently of each other. In HeLa cell transfec...
متن کاملGap junctional communication in health and disease
Gap junctions (GJ) provide intercellular communication in all multicellular animal species, being as evolutionary distant as worm and men. In the traditional view GJs are known as specialized cell junctions forming communicating channels connecting the cytoplasm of adjacent cells. In almost all tissues GJ coupled cells can rapidly exchange ions, nutrients, or small metabolites to establish elec...
متن کاملTellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro.
Tellimagrandin I and chebulinic acid, two hydrolysable tannins, have been shown to exert anti-tumor properties. Dysfunctional gap junctional communication (GJIC) has been recognized as being involved in carcinogenesis. The human cervical carcinoma HeLa cells have been reported to be deficient in functional GJIC. In present study, we investigated whether tellimagrandin I and chebulinic acid migh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1998
ISSN: 1460-2180
DOI: 10.1093/carcin/19.5.747